Biology of Ageing

Diabetes accelerates age-related defenestration of the liver sinusoid

HA Jamieson, VC Cogger, R Cheluvappa, R Fraser, SM Twigg, SV McClennan, R de Cabo, DG Le Couteur

In this work we demonstrated that diabetes caused an increase in age-related defenestration. This confirms that the age-related loss of fenestrae can be accelerated. We hypothesised that this may contribute to the delayed chylomicron remnant clearance and the increased rate of atherosclerosis that occurs in diabetes.